Our researchWe are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.
We are also involved in developing protocols for protein delivery in using retroviral modified vectors. |
Translational control of the inflammatory responseCells of the innate immune system have to respond rapidly to a wide-range of stimuli. This response is accompanied by the activation of a complex genetic program that involves a myriad of transcriptional and post-transcriptional regulatory mechanisms. In this dynamic context, we are studying the role of mRNA translation regulation in modulating the innate immune response.
|
Post-transcriptional control during retroviral infectionViruses are intracellular parasites that intimately interact with the host cell in order to replicate. Interestingly, all known viruses strictly depend on the cell's translational machinery to synthesise new viral proteins. Using high-throughput sequencing approaches we aim at understanding how translation is orchestrated during the replication cycle.
|
Using retroviruses as protein delivery platformsThanks to their capacity to integrate their viral genome into the host cell genome, retroviral vectors have been historically used as gene delivery platforms. However, retroviruses can also be engineered to act as protein cargos in the absence of any viral genetic material. These modified retroviral vectors can efficiently deliver their protein cargo in a rapid and transient fashion.
|